Fast-talking New Yorker and brand new doctor Zoe Hart has it all figured out - after graduating top of her class from medical school, she'll follow in her father's footsteps and become a cardio-thoracic surgeon. But when her dreams fall apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama. Zoe arrives in this small Gulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.

Recounting the chaotic events that occurred in Dallas, Texas on November 22, 1963, Parkland weaves together the perspectives of a handful of ordinary individuals suddenly thrust into extraordinary circumstances: the young doctors and nurses at Parkland Hospital; Dallas' chief of the Secret Service; an unwitting cameraman who captured what became the most watched and examined film in history; the FBI agents who nearly had the gunman within their grasp; the brother of Lee Harvey Oswald, left to deal with his shattered family; and JFK's security team, witnesses to both the president's death and Vice President Lyndon Johnson's rise to power over a nation whose innocence was forever altered.

A teenage girl, distraught from her vain attempt to connect with her estranged mother, resorts to cutting herself. When she develops an online relationship with an older woman, she learns to accept her sexuality and the endless solitude of sprawling suburbia.